Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 1/20 | 0.50 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.43 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.43 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.43 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29101911 | 0.85 | TAAR1 (0.44) | SMN1; SMN2TAAR1SIGMAR1PLAAT3PLAAT5 | |
| SCHEMBL4713692 | 0.85 | TAAR1 (0.44) | KMT2ASMN1; SMN2TAAR1ALDH1A1TSHR | |
| SCHEMBL22160576 | 0.80 | TLR2 (0.76) | TLR2TLR1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL22160628 | 0.80 | TLR2 (0.76) | TLR2TLR1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL22160600 | 0.80 | TLR2 (0.76) | TLR2TLR1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL22160492 | 0.77 | TLR2 (0.71) | TLR2TLR1KMT2AMEN1TAAR1 | |
| SCHEMBL22160493 | 0.77 | TLR2 (0.71) | TLR2TLR1KMT2AMEN1TAAR1 | |
| SCHEMBL22160494 | 0.77 | TLR2 (0.71) | TLR2TLR1KMT2AMEN1TAAR1 | |
| SCHEMBL2466298 | 0.76 | TAAR1 (0.53) | TAAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4715540 | 0.75 | NPC1 (0.45) | KMT2AMEN1TAAR1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933830-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | Vernalis (R&D) Limited (GB) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007007057-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | VERNALIS (R & D) LIMITED (GB) | 2007-01-18 | — | — | WO | disclosed |