Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4713692 | 0.83 | TAAR1 (0.44) | NPC1RAB9APOLBTAAR1KMT2A | |
| SCHEMBL4716650 | 0.76 | TP53 (0.42) | NPC1RAB9APOLBTAAR1MEN1 | |
| SCHEMBL29101911 | 0.75 | TAAR1 (0.44) | NPC1TAAR1CNR1DRD4 | |
| SCHEMBL4713876 | 0.75 | TLR2 (0.50) | TAAR1MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL11895626 | 0.74 | NPC1 (0.65) | NPC1RAB9AAKR1C3POLBTAAR1 | |
| SCHEMBL15054786 | 0.72 | TAAR1 (0.66) | NPC1RAB9ATAAR1MEN1KMT2A | |
| SCHEMBL4342706 | 0.72 | TAAR1 (0.66) | NPC1RAB9ATAAR1MEN1KMT2A | |
| SCHEMBL3316633 | 0.70 | SLC6A9 (0.44) | MEN1KMT2AGAA | |
| SCHEMBL10112805 | 0.69 | HDAC3 (0.59) | NPC1RAB9APOLBHDAC3HDAC1 | |
| SCHEMBL3213481 | 0.69 | HDAC3 (0.52) | NPC1RAB9AAKR1C3POLBTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933830-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | Vernalis (R&D) Limited (GB) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007007057-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | VERNALIS (R & D) LIMITED (GB) | 2007-01-18 | — | — | WO | disclosed |