Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.43 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.43 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.43 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4713876 | 0.85 | TLR2 (0.50) | TAAR1SMN1; SMN2PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL29101911 | 0.85 | TAAR1 (0.44) | TAAR1SMN1; SMN2HPGDPLAAT3PLAAT5 | |
| SCHEMBL4715540 | 0.83 | NPC1 (0.45) | TAAR1POLBALDH1A1NPC1RAB9A | |
| SCHEMBL22160691 | 0.80 | TLR2 (0.57) | TAAR1POLBTP53HPGDALDH1A1 | |
| SCHEMBL22160693 | 0.80 | TLR2 (0.57) | TAAR1POLBTP53HPGDALDH1A1 | |
| SCHEMBL22160688 | 0.80 | TLR2 (0.57) | TAAR1POLBTP53HPGDALDH1A1 | |
| SCHEMBL4716650 | 0.77 | TP53 (0.42) | TAAR1POLBTP53HPGDALDH1A1 | |
| SCHEMBL2466540 | 0.76 | GRIN2B (0.51) | TAAR1POLBALDH1A1KMT2ATSHR | |
| Formic Acid SCHEMBL5071632 | 0.74 | TAAR1 (0.48) | TAAR1POLBSMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL15054786 | 0.73 | TAAR1 (0.66) | TAAR1TP53SMN1; SMN2HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933830-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | Vernalis (R&D) Limited (GB) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007007057-A1 | ANTAGONISTS OF SNS SODIUM CHANNELS | VERNALIS (R & D) LIMITED (GB) | 2007-01-18 | — | — | WO | disclosed |