Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 5/20 | 0.78 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ASIC1 | P78348 | 1/20 | 0.36 |
| ▸ | PKN1 | Q16512 | 5/20 | 0.36 |
| ▸ | PKN2 | Q16513 | 5/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | PRKCH | P24723 | 1/20 | 0.34 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14188300 | 0.88 | CDC7 (1.00) | CDC7GRM5PIM1PIM2PKN1 | |
| Trifluoroacetic Acid SCHEMBL4997521 | 0.84 | CDC7 (0.55) | CDC7GRM5PIM1PIM2ASIC1 | |
| Trifluoroacetic Acid SCHEMBL4999615 | 0.84 | CDC7 (0.55) | CDC7GRM5PIM1PIM2PIK3C3 | |
| Trifluoroacetic Acid SCHEMBL4997167 | 0.82 | CDC7 (0.53) | CDC7PIM1PIM2ASIC1PIK3C3 | |
| Trifluoroacetic Acid SCHEMBL5000129 | 0.82 | CDC7 (0.53) | CDC7GRM5PIM1PIM2ASIC1 | |
| SCHEMBL26645506 | 0.82 | CDC7 (0.72) | CDC7PIM1PIM2 | |
| Trifluoroacetic Acid SCHEMBL4716136 | 0.82 | CDC7 (0.52) | CDC7PIM1PIM2PIK3C3DPP4 | |
| Trifluoroacetic Acid SCHEMBL4715188 | 0.81 | CDC7 (0.52) | CDC7 | |
| Trifluoroacetic Acid SCHEMBL4996147 | 0.81 | CDC7 (0.52) | CDC7PIM1PIM2ASIC1BRAF | |
| Trifluoroacetic Acid SCHEMBL4997001 | 0.81 | CDC7 (0.52) | CDC7PIM1PIM2PIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113971-A1 | PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | HANAU CATHLEEN E | 2008-05-15 | — | — | US | disclosed |
| EP-1572682-A4 | ACYCLIC PYRAZOLE COMPOUNDS | PHARMACIA CORP (US) | 2008-01-23 | — | — | EP | disclosed |
| EP-1572682-A2 | ACYCLIC PYRAZOLE COMPOUNDS | Pharmacia Corporation (US) | 2005-09-14 | — | — | EP | disclosed |
| US-20040152739-A1 | Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-08-05 | — | — | US | disclosed |
| WO-2004058176-A2 | ACYCLIC PYRAZOLE COMPOUNDS | PHARMACIA CORPORATION (US) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113971-A1 | PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS | MKNK2, MAPKAPK2, MAP3K2 | CDC7 487/4885GRM5 1129/4885PIM1 539/4885 |
| US-20040152739-A1 | Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MAPKAPK2, MAP3K2, MAP4K2 | CDC7 331/4885GRM5 948/4885PIM1 790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.