Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TTR | P02766 | 2/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4714220 | 1.00 | KDM4E (0.45) | KDM4ETDP1CYP3A4ALOX12NFE2L2 | |
| SCHEMBL4710419 | 0.82 | NFE2L2 (0.52) | NFE2L2AHR | |
| SCHEMBL4710418 | 0.82 | NFE2L2 (0.52) | NFE2L2AHR | |
| SCHEMBL4711297 | 0.81 | KDM4E (0.48) | KDM4ETDP1CYP3A4ALOX12NFE2L2 | |
| SCHEMBL4790285 | 0.79 | NFE2L2 (0.48) | KDM4ETDP1CYP3A4ALOX12NFE2L2 | |
| SCHEMBL4790286 | 0.79 | NFE2L2 (0.48) | KDM4ETDP1CYP3A4ALOX12NFE2L2 | |
| SCHEMBL4710439 | 0.79 | KMT2A (0.40) | KDM4ETDP1CYP3A4KMT2AMEN1 | |
| SCHEMBL4710440 | 0.79 | KMT2A (0.40) | KDM4ETDP1CYP3A4KMT2AMEN1 | |
| SCHEMBL4712497 | 0.74 | AHR (0.44) | NFE2L2AHR | |
| SCHEMBL4712494 | 0.74 | AHR (0.44) | NFE2L2AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-A2 | PYRIDINE DERIVATIVES | Novartis AG (CH) | 2000-05-10 | — | — | EP | claimed |
| WO-1999002497-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 1999-01-21 | — | — | WO | claimed |
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |