Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.36 |
| ▸ | PLK1 | P53350 | 2/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | AKT1 | P31749 | 2/20 | 0.34 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.34 |
| ▸ | OXTR | P30559 | 1/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4889888 | 0.81 | NOTUM (0.38) | NOTUMRORCAKT1MGLL | |
| SCHEMBL4881720 | 0.81 | NOTUM (0.38) | NOTUMRORCAKT1 | |
| SCHEMBL3743361 | 0.71 | NOTUM (0.58) | NOTUMAKT1 | |
| SCHEMBL4761770 | 0.70 | EPHX2 (0.43) | — | |
| SCHEMBL5578912 | 0.69 | NOTUM (0.49) | NOTUMRORCHDAC1HDAC6 | |
| SCHEMBL5578616 | 0.68 | NOTUM (0.46) | NOTUMHDAC1HDAC6 | |
| SCHEMBL5579022 | 0.67 | SIGMAR1 (0.38) | RORCHDAC1HDAC6 | |
| SCHEMBL7542146 | 0.67 | NPC1 (0.43) | RORCAKT1HDAC1HDAC6 | |
| SCHEMBL9047131 | 0.67 | NOTUM (0.53) | NOTUMAKT1HDAC1HDAC6 | |
| SCHEMBL5578781 | 0.67 | NOTUM (0.47) | NOTUMRORCMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899339-A1 | 1,2-DIHYDRO-SPIRO(3H-INDOLE-3-4 -PIPERIDINE) COMPOUNDS AS MODULATORS OF THE MAS RECEPTOR NOVEL | Arena Pharmaceuticals, Inc. (US) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007002114-A1 | 1,2-DIHYDRO-SPIRO(3H-INDOLE-3-4’-PIPERIDINE) COMPOUNDS AS MODULATORS OF THE MAS RECEPTOR NOVEL | ARENA PHARMACEUTICALS, INC. (US) | 2007-01-04 | — | — | WO | disclosed |