Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 1/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 10/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4015429 | 0.79 | HSPB1 (0.49) | HSPB1TRPA1MAPK14MAP4K4MEN1 | |
| SCHEMBL4015528 | 0.74 | MAPT (0.47) | HSPB1TRPA1MAPK14BRD4KDM4E | |
| SCHEMBL8469819 | 0.74 | HSPB1 (0.59) | HSPB1TRPA1MAPK14MAP4K4KDM4E | |
| SCHEMBL11951790 | 0.70 | FFAR4 (0.42) | KDM4EMEN1KMT2A | |
| SCHEMBL27297629 | 0.69 | HSPB1 (0.56) | HSPB1MAPK14MAP4K4KDM4EMEN1 | |
| SCHEMBL12825878 | 0.68 | TRPA1 (0.56) | HSPB1TRPA1MAP4K4 | |
| SCHEMBL24298069 | 0.68 | HSPB1 (0.52) | HSPB1TRPA1MAPK14MAP4K4MEN1 | |
| SCHEMBL17141626 | 0.68 | HSPB1 (0.59) | HSPB1TRPA1MAPK14MAP4K4KDM4E | |
| SCHEMBL428509 | 0.68 | HSPB1 (0.59) | HSPB1TRPA1MAPK14MAP4K4KDM4E | |
| SCHEMBL3351203 | 0.68 | HSPB1 (0.59) | HSPB1TRPA1MAPK14MAP4K4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919470-A1 | FUSED PYRAZOLE AS p38 MAP KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007023105-A1 | FUSED PYRAZOLE AS p38 MAP KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-01 | — | — | WO | disclosed |
| EP-1720878-A1 | HETEROARYL-FUSED PYRAZOLO DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005085248-A1 | HETEROARYL-FUSED PYRAZOLO DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2005-09-15 | — | — | WO | disclosed |