Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4714726 | 1.00 | CYP19A1 (0.46) | CYP19A1MEN1KMT2AMAPTAR | |
| SCHEMBL4710055 | 0.83 | KMT2A (0.44) | MEN1KMT2AMAPTALDH1A1RAB9A | |
| SCHEMBL4710053 | 0.83 | KMT2A (0.44) | MEN1KMT2AMAPTALDH1A1RAB9A | |
| SCHEMBL4710786 | 0.81 | MEN1 (0.54) | CYP19A1MEN1KMT2AMAPTAR | |
| SCHEMBL4710787 | 0.81 | MEN1 (0.54) | CYP19A1MEN1KMT2AMAPTAR | |
| SCHEMBL4712062 | 0.80 | RAB9A (0.48) | CYP19A1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL4712063 | 0.80 | RAB9A (0.48) | CYP19A1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL7268783 | 0.77 | MAPT (0.48) | MEN1KMT2AMAPTALDH1A1RAB9A | |
| SCHEMBL27496603 | 0.75 | ALDH1A1 (0.44) | CYP19A1MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL27496602 | 0.74 | BACE1 (0.46) | CYP19A1MEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | claimed |
| EP-0998459-A2 | PYRIDINE DERIVATIVES | Novartis AG (CH) | 2000-05-10 | — | — | EP | claimed |
| WO-1999002497-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 1999-01-21 | — | — | WO | claimed |
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |