Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 5/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.48 |
| ▸ | ANPEP | P15144 | 2/20 | 0.47 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.47 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1619118 | 0.81 | SLC6A2 (0.56) | SLC6A2TAAR1ANPEPSLC6A4SLC6A3 | |
| SCHEMBL8409870 | 0.80 | ANPEP (0.49) | ANPEPERAP1ERAP2SMN1; SMN2GRIK1 | |
| Hydrochloric Acid SCHEMBL7066881 | 0.79 | SLC6A2 (0.54) | SLC6A2TAAR1ANPEPSLC6A4SLC6A3 | |
| SCHEMBL7953179 | 0.79 | ANPEP (0.47) | SLC6A2TAAR1ANPEPERAP1ERAP2 | |
| Hydrochloric Acid SCHEMBL7836848 | 0.78 | ANPEP (0.47) | ANPEPERAP1ERAP2SMN1; SMN2GRIK1 | |
| SCHEMBL8676302 | 0.77 | KDM4E (0.42) | SLC6A2TAAR1ANPEPERAP1ERAP2 | |
| SCHEMBL28615047 | 0.76 | ANPEP (0.44) | TAAR1ANPEPERAP1ERAP2CYP2A6 | |
| SCHEMBL8067994 | 0.76 | SLC6A2 (0.45) | SLC6A2TAAR1ANPEPERAP1ERAP2 | |
| SCHEMBL894528 | 0.76 | SLC6A2 (0.60) | SLC6A2TAAR1ANPEPERAP1ERAP2 | |
| SCHEMBL605244 | 0.76 | SLC6A2 (0.60) | SLC6A2TAAR1ANPEPERAP1ERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877401-A2 | NOVEL COMPOUNDS USEFUL FOR BRADYKININ B1 RECEPTOR ANTAGONISM | Elan Pharmaceuticals Inc. (US) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006113140-A2 | NOVEL COMPOUNDS USEFUL FOR BRADYKININ B1 RECEPTOR ANTAGONISM | ELAN PHARMACEUTICALS, INC. (US) | 2006-10-26 | — | — | WO | disclosed |