Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.57 |
| ▸ | KIF11 | P52732 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10831632 | 0.79 | TAAR1 (0.56) | TAAR1KIF11SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8352931 | 0.77 | KIF11 (0.41) | TAAR1KIF11 | |
| Hydrochloric Acid SCHEMBL6013495 | 0.74 | TAAR1 (0.42) | TAAR1KIF11SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6681969 | 0.74 | TAAR1 (0.54) | TAAR1MAPK1 | |
| SCHEMBL323323 | 0.73 | TAAR1 (1.00) | TAAR1KIF11SLC6A2MAPK1MAPT | |
| SCHEMBL2396652 | 0.73 | KIF11 (0.58) | TAAR1KIF11 | |
| SCHEMBL2396656 | 0.73 | KIF11 (0.58) | TAAR1KIF11 | |
| SCHEMBL21408970 | 0.73 | TAAR1 (0.48) | TAAR1KIF11MAPK1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL3052766 | 0.72 | TAAR1 (0.95) | TAAR1KIF11SLC6A2MAPK1MAPT | |
| SCHEMBL9768637 | 0.71 | TAAR1 (0.50) | TAAR1KIF11SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877401-A2 | NOVEL COMPOUNDS USEFUL FOR BRADYKININ B1 RECEPTOR ANTAGONISM | Elan Pharmaceuticals Inc. (US) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006113140-A2 | NOVEL COMPOUNDS USEFUL FOR BRADYKININ B1 RECEPTOR ANTAGONISM | ELAN PHARMACEUTICALS, INC. (US) | 2006-10-26 | — | — | WO | disclosed |