Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4721313 | 0.88 | STS (0.46) | NR1H2ALDH1A1ESR2NAMPTUSP30 | |
| SCHEMBL4718766 | 0.88 | USP30 (0.42) | NR1H2ALDH1A1ESR2NAMPTNPC1 | |
| SCHEMBL4718638 | 0.86 | TGFBR1 (0.44) | NR1H2ALDH1A1ESR2NAMPTNPC1 | |
| SCHEMBL4714474 | 0.84 | GPR119 (0.47) | NR1H2ALDH1A1ESR2NAMPTNPC1 | |
| SCHEMBL4716513 | 0.80 | TGFBR1 (0.54) | — | |
| SCHEMBL31730567 | 0.75 | NR1H2 (0.56) | NR1H2ALDH1A1ESR2NAMPTMAPK1 | |
| SCHEMBL29377835 | 0.73 | NR1H2 (0.90) | NR1H2ESR2NAMPTNPC1RAB9A | |
| SCHEMBL29507781 | 0.73 | NR1H2 (1.00) | NR1H2ESR2NAMPTNPC1RAB9A | |
| SCHEMBL308035 | 0.73 | NR1H2 (1.00) | NR1H2ESR2NAMPTNPC1RAB9A | |
| SCHEMBL61143 | 0.73 | NR1H2 (0.90) | NR1H2ESR2NAMPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216230-B1 | FUSED CYCLOHEPTANE AND FUSED AZACYCLOHEPTANE COMPOUNDS AND THEIR USE AS INTEGRIN RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2008-04-23 | — | — | EP | disclosed |
| US-6514964-B1 | Treating diseases, conditions or disorders mediated by integrin receptors, such as vitronectin and fibronectin receptors | AMGEN INC. | 2003-02-04 | — | — | US | disclosed |