Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 12/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 12/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4711023 | 0.88 | TAAR1 (0.41) | HCRTR1HCRTR2CTSBCTSS | |
| SCHEMBL4716949 | 0.85 | HDAC3 (0.38) | KCNH2HCRTR1HCRTR2MEN1KMT2A | |
| SCHEMBL1845666 | 0.82 | MEN1 (0.46) | MEN1KMT2ANPC1RAB9ATDP1 | |
| SCHEMBL4819083 | 0.81 | TAAR1 (0.41) | HCRTR1HCRTR2CTSBCTSS | |
| SCHEMBL25046666 | 0.80 | L3MBTL1 (0.45) | MEN1KMT2ANPC1RAB9ATDP1 | |
| SCHEMBL18845331 | 0.79 | HDAC3 (0.50) | MEN1KMT2ANPC1RAB9ATDP1 | |
| SCHEMBL4714957 | 0.79 | L3MBTL1 (0.35) | MEN1KMT2AHDAC1L3MBTL1HTR2C | |
| SCHEMBL26995509 | 0.79 | L3MBTL1 (0.47) | MEN1KMT2ANPC1RAB9ATDP1 | |
| SCHEMBL2260891 | 0.78 | MEN1 (0.45) | MEN1KMT2ANPC1RAB9ATDP1 | |
| SCHEMBL9823156 | 0.78 | HDAC1 (0.54) | MEN1KMT2ANPC1RAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1677799-A4 | TRIAZOLO-PYRIDAZINE COMPOUNDS AND DERIVATIVES THEREOF USEFUL IN THE TREATMENT OF NEUROPATHIC PAIN | MERCK & CO INC (US) | 2008-09-10 | — | — | EP | disclosed |
| EP-1677799-A1 | TRIAZOLO-PYRIDAZINE COMPOUNDS AND DERIVATIVES THEREOF USEFUL IN THE TREATMENT OF NEUROPATHIC PAIN | Merck & Co., Inc. (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005041971-A1 | TRIAZOLO-PYRIDAZINE COMPOUNDS AND DERIVATIVES THEREOF USEFUL IN THE TREATMENT OF NEUROPATHIC PAIN | MERCK & CO., INC. (US) | 2005-05-12 | — | — | WO | disclosed |