Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 16/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11590712 | 1.00 | AR (0.55) | ARADORA1ADORA2AKDM4EALDH1A1 | |
| SCHEMBL30681004 | 0.88 | ADORA1 (0.47) | ARADORA1ADORA2AKDM4EALDH1A1 | |
| SCHEMBL11721081 | 0.76 | ALDH1A1 (0.50) | ARKDM4EALDH1A1KMT2A | |
| SCHEMBL7978388 | 0.76 | ADORA1 (0.61) | ADORA1ADORA2AKDM4EALDH1A1KMT2A | |
| SCHEMBL11591796 | 0.76 | ADORA1 (0.53) | ADORA1ADORA2AKDM4EALDH1A1KMT2A | |
| SCHEMBL31624491 | 0.75 | ADORA1 (0.60) | ADORA1ADORA2AKDM4EALDH1A1KMT2A | |
| SCHEMBL11723044 | 0.75 | AR (0.44) | ARADORA1ADORA2AKDM4EALDH1A1 | |
| SCHEMBL25419293 | 0.73 | ALDH1A1 (0.46) | ARADORA1ADORA2AKDM4EALDH1A1 | |
| SCHEMBL30461719 | 0.73 | ALDH1A1 (0.46) | ARADORA1ADORA2AKDM4EALDH1A1 | |
| SCHEMBL11592378 | 0.72 | ADORA1 (0.53) | ARADORA1ADORA2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4208166-A1 | IMIDAZONAPHTHYRIDINES AND IMIDAZOPYRIDOPYRIMIDINES AS IFNAR2 AGONISTS FOR TREATING SARS-COV-2 INFECTIONS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2023-07-12 | — | — | EP | disclosed |
| WO-2022049521-A1 | IMIDAZONAPHTHYRIDINES AND IMIDAZOPYRIDOPYRIMIDINES AS IFNAR2 AGONISTS FOR TREATING SARS-COV-2 INFECTIONS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2022-03-10 | — | — | WO | disclosed |