Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.55 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.55 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.55 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.53 |
| ▸ | TFEB | P19484 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1711263 | 1.00 | HTT (0.63) | HTTGAASMN1; SMN2KDM4EPTGER1 | |
| SCHEMBL1711265 | 1.00 | HTT (0.63) | HTTGAASMN1; SMN2KDM4EPTGER1 | |
| SCHEMBL13036867 | 0.88 | NFE2L2 (0.69) | HTTKDM4EMEN1KMT2ANFKB1 | |
| SCHEMBL20110943 | 0.88 | KDM4E (0.72) | HTTKDM4EMEN1KMT2ANFE2L2 | |
| SCHEMBL1603612 | 0.87 | MEN1 (0.60) | SMN1; SMN2KDM4EMEN1KMT2ANFKB1 | |
| SCHEMBL16498326 | 0.85 | MAPT (0.72) | HTTSMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL16498329 | 0.85 | MAPT (0.72) | HTTSMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL17305571 | 0.85 | KDM4E (0.54) | HTTGAAKDM4EMEN1KMT2A | |
| SCHEMBL4712845 | 0.85 | KDM4E (0.54) | HTTGAASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL18121457 | 0.85 | KDM4E (0.54) | HTTGAAKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054004-B1 | NOVEL PYRIMIDINE-5-CARBOXAMIDE DERIVATIVES | ASTELLAS PHARMA INC (JP) | 2008-07-16 | — | — | EP | disclosed |
| US-6432963-B1 | ANTIINFLAMMATORY AGENTS; TYROSINE KINASE INHIBITOR | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2002-08-13 | — | — | US | disclosed |
| EP-1054004-A1 | NOVEL PYRIMIDINE-5-CARBOXAMIDE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2000-11-22 | — | — | EP | disclosed |