Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 6/20 | 0.52 |
| ▸ | KDR | P35968 | 13/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.49 |
| ▸ | TNNI3K | Q59H18 | 8/20 | 0.49 |
| ▸ | BRAF | P15056 | 6/20 | 0.49 |
| ▸ | RAF1 | P04049 | 2/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3253663 | 0.88 | PSEN1 (0.45) | FLT3KDRMAPK14TNNI3KBRAF | |
| SCHEMBL3247880 | 0.87 | KDR (0.66) | FLT3KDRMAPK14TNNI3KBRAF | |
| SCHEMBL2840607 | 0.81 | KDR (0.56) | FLT3KDRMAPK14TNNI3KBRAF | |
| SCHEMBL2850437 | 0.80 | KDR (0.73) | FLT3KDRMAPK14TNNI3KBRAF | |
| SCHEMBL3256674 | 0.77 | KDR (0.57) | FLT3KDRMAPK14TNNI3KBRAF | |
| SCHEMBL574203 | 0.73 | KIF11 (0.42) | KDRRAF1PSEN1PSEN2APH1B | |
| SCHEMBL2845926 | 0.72 | KDR (0.56) | FLT3KDRMAPK14TNNI3KBRAF | |
| SCHEMBL2843359 | 0.70 | NR2E1 (0.55) | KDRCSF1RPDGFRBKITPDGFRA | |
| SCHEMBL2851874 | 0.70 | SRC (0.67) | FLT3KDRMAPK14TNNI3KBRAF | |
| SCHEMBL12999021 | 0.69 | KDR (0.43) | FLT3KDRMAPK14TNNI3KBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940844-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2008-07-09 | — | — | EP | claimed |
| WO-2007053343-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2007-05-10 | — | — | WO | claimed |
| EP-1940844-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007053343-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2007-05-10 | — | — | WO | disclosed |