Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.66 |
| ▸ | BRAF | P15056 | 6/20 | 0.66 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.66 |
| ▸ | TNNI3K | Q59H18 | 6/20 | 0.66 |
| ▸ | FLT3 | P36888 | 7/20 | 0.56 |
| ▸ | CSF1R | P07333 | 3/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 2/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3256674 | 0.90 | KDR (0.57) | KDRBRAFMAPK14TNNI3KFLT3 | |
| SCHEMBL4715500 | 0.87 | FLT3 (0.52) | KDRBRAFMAPK14TNNI3KFLT3 | |
| SCHEMBL25405811 | 0.81 | KDR (0.81) | KDRBRAFMAPK14TNNI3KFLT3 | |
| SCHEMBL2845565 | 0.81 | KDR (0.66) | KDRBRAFMAPK14TNNI3KFLT3 | |
| SCHEMBL2848934 | 0.80 | KDR (1.00) | KDRBRAFMAPK14TNNI3KFLT3 | |
| SCHEMBL3253663 | 0.75 | PSEN1 (0.45) | KDRBRAFMAPK14TNNI3KFLT3 | |
| SCHEMBL2846085 | 0.75 | KDR (0.64) | KDRBRAFMAPK14TNNI3KFLT3 | |
| SCHEMBL574203 | 0.73 | KIF11 (0.42) | KDRRAF1 | |
| SCHEMBL3831817 | 0.73 | KDR (0.77) | KDRBRAFMAPK14TNNI3KFLT3 | |
| SCHEMBL4716357 | 0.73 | ABL1 (0.51) | BRAFMAPK14RAF1MAP3K7MAP4K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056907-A2 | COMPOUNDS THAT INDUCE PANCREATIC BETA-CELL EXPANSION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-05-20 | — | — | WO | claimed |
| EP-1940844-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2008-07-09 | — | — | EP | claimed |
| WO-2007053343-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2007-05-10 | — | — | WO | claimed |
| EP-1940844-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007053343-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2007-05-10 | — | — | WO | disclosed |