Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3140172 | 0.89 | MAPT (0.58) | POLBFFAR1KYAT1MAPTGAA | |
| SCHEMBL11020358 | 0.87 | TOP2A (0.50) | POLBMAPTGAATDP1TOP2A | |
| SCHEMBL3203778 | 0.84 | POLB (0.68) | POLBFFAR1MAPTGAATDP1 | |
| SCHEMBL11317541 | 0.81 | MAPT (0.54) | POLBKYAT1MAPTGAATOP2A | |
| SCHEMBL5792896 | 0.80 | GAA (0.53) | POLBKYAT1MAPTGAATOP2A | |
| SCHEMBL6829598 | 0.79 | GAA (0.51) | POLBMAPTGAAALDH1A1KMT2A | |
| SCHEMBL28470217 | 0.78 | MAPT (0.66) | POLBFFAR1MAPTGAAALDH1A1 | |
| SCHEMBL16839943 | 0.78 | NPC1 (0.61) | POLBFFAR1MAPTTOP2AALDH1A1 | |
| SCHEMBL3129089 | 0.78 | POLB (0.61) | POLBFFAR1MAPTALDH1A1KMT2A | |
| SCHEMBL9829525 | 0.76 | MAPT (0.53) | POLBFFAR1MAPTGAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957073-A2 | MEDICINAL DRUG | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007066784-A2 | DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-06-14 | — | — | WO | disclosed |
| EP-1773797-A2 | AROMATIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006014012-A2 | AROMATIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-02-09 | — | — | WO | disclosed |