Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 6/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4878429 | 0.88 | KIF11 (0.46) | KIF11CYP3A4MAP1LC3BCYP2C19KCNH2 | |
| SCHEMBL12393646 | 0.82 | KIF11 (0.54) | KIF11CYP3A4MAP1LC3BCYP2C19KCNH2 | |
| SCHEMBL5724300 | 0.82 | KIF11 (0.55) | KIF11CYP3A4MAP1LC3BCYP2C19KCNH2 | |
| SCHEMBL4519529 | 0.78 | KIF11 (0.56) | KIF11CYP3A4MAP1LC3BCYP2C19KCNH2 | |
| SCHEMBL4283747 | 0.78 | KIF11 (0.56) | KIF11CYP3A4MAP1LC3BCYP2C19KCNH2 | |
| SCHEMBL5648396 | 0.78 | KIF11 (0.56) | KIF11CYP3A4MAP1LC3BCYP2C19KCNH2 | |
| SCHEMBL4619180 | 0.77 | KIF11 (0.58) | KIF11CYP3A4MAP1LC3BCYP2C19KCNH2 | |
| SCHEMBL14078088 | 0.77 | KIF11 (0.58) | KIF11CYP3A4MAP1LC3BCYP2C19KCNH2 | |
| SCHEMBL5723915 | 0.76 | KIF11 (0.61) | KIF11CYP3A4MAP1LC3BCYP2C19KCNH2 | |
| SCHEMBL5723804 | 0.76 | KIF11 (0.61) | KIF11CYP3A4MAP1LC3BCYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537089-A4 | COMPOUNDS COMPOSITIONS AND METHODS | CYTOKINETICS INC (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1537089-A2 | COMPOUNDS COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004009036-A2 | COMPOUNDS COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2004-01-29 | — | — | WO | disclosed |