Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 15/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.36 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4717476 | 0.92 | NAMPT (0.42) | NAMPT | |
| SCHEMBL4790644 | 0.89 | NAMPT (0.42) | NAMPTITGB3ITGAVITGA2B | |
| SCHEMBL4761347 | 0.85 | NAMPT (0.43) | NAMPTITGB3ITGAVITGA2B | |
| SCHEMBL4760275 | 0.85 | NAMPT (0.39) | NAMPTITGB3ITGAVITGA2B | |
| Hydrochloric Acid SCHEMBL4760424 | 0.85 | NAMPT (0.43) | NAMPTITGB3ITGAVITGA2B | |
| SCHEMBL4762054 | 0.81 | NAMPT (0.42) | NAMPTITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL4717310 | 0.81 | KEAP1 (0.50) | NAMPTCACNA1GCACNA1HCACNA1I | |
| SCHEMBL4789561 | 0.79 | ITGAV (0.57) | ITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL4791224 | 0.79 | ITGAV (0.57) | ITGB3ITGAVITGA2BITGB5 | |
| SCHEMBL4761797 | 0.78 | ITGB3 (0.53) | NAMPTITGB3ITGAVITGA2BITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216230-B1 | FUSED CYCLOHEPTANE AND FUSED AZACYCLOHEPTANE COMPOUNDS AND THEIR USE AS INTEGRIN RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2008-04-23 | — | — | EP | disclosed |
| EP-1216230-B1 | FUSED CYCLOHEPTANE AND FUSED AZACYCLOHEPTANE COMPOUNDS AND THEIR USE AS INTEGRIN RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2008-04-23 | — | — | EP | disclosed |