Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 2/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.40 |
| ▸ | P4HA1 | P13674 | 2/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4281565 | 0.80 | MAPK1 (0.44) | KDM4ENPC1RAB9ATDP1L3MBTL1 | |
| SCHEMBL1219671 | 0.78 | KDM4E (0.40) | KDM4EPIK3CDALDH1A1PSMD14 | |
| SCHEMBL27609657 | 0.73 | NPC1 (0.72) | KDM4ENPC1RAB9AHKDC1TDP1 | |
| SCHEMBL5262551 | 0.73 | MGAM (0.42) | KDM4ENPC1RAB9AHKDC1TDP1 | |
| SCHEMBL11688888 | 0.71 | NPC1 (0.51) | KDM4ENPC1RAB9AHKDC1TDP1 | |
| SCHEMBL23858342 | 0.70 | KDM4E (0.54) | KDM4ENPC1RAB9AHKDC1TDP1 | |
| SCHEMBL30917341 | 0.70 | NPC1 (0.74) | KDM4ENPC1RAB9AHKDC1TDP1 | |
| SCHEMBL261022 | 0.70 | NPC1 (0.74) | KDM4ENPC1RAB9AHKDC1TDP1 | |
| SCHEMBL30251663 | 0.70 | KDM4E (0.54) | KDM4ENPC1RAB9AHKDC1TDP1 | |
| SCHEMBL25425637 | 0.70 | MGAM (0.44) | KDM4ENPC1RAB9ATDP1MGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3490995-A1 | SUBSTITUTED THIAZOLO-PYRIDINE COMPOUNDS AS MALT1 INHIBITORS | Lupin Limited (IN) | 2019-06-05 | — | — | EP | disclosed |
| WO-2018020474-A1 | SUBSTITUTED THIAZOLO-PYRIDINE COMPOUNDS AS MALT1 INHIBITORS | LUPIN LIMITED (IN) | 2018-02-01 | — | — | WO | disclosed |
| EP-2864338-A2 | 7-OXO-THIAZOLOPYRIDINE CARBONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE | Savira Pharmaceuticals GmbH (AT) | 2015-04-29 | — | — | EP | disclosed |
| EP-2861232-A1 | 7-OXO-4,7 -DIHYDRO- PYRAZOLO [1, 5 -A]PYRIMIDINE DERIVATIVES WHICH ARE USEFUL IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE | Savira Pharmaceuticals GmbH (AT) | 2015-04-22 | — | — | EP | disclosed |
| WO-2013174930-A2 | 7-OXO-THIAZOLOPYRIDINE CARBONIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE | SAVIRA PHARMACEUTICALS GMBH (AT) | 2013-11-28 | — | — | WO | disclosed |
| WO-2013174931-A1 | 7-OXO-4,7 -DIHYDRO- PYRAZOLO [1, 5 -A] PYRIMIDINE DERIVATIVES WHICH ARE USEFUL IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE | SAVIRA PHARMACEUTICALS GMBH (AT) | 2013-11-28 | — | — | WO | disclosed |
| EP-1625126-B1 | IMIDAZO AND THIAZOLOPYRIDINES AS JAK3 KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-01-16 | — | — | EP | disclosed |
| US-3953461-A | CNS DEPRESSANTS, ANTIINFLAMMATORY AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1976-04-27 | — | — | US | disclosed |
| US-3953461-A | CNS DEPRESSANTS, ANTIINFLAMMATORY AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1976-04-27 | — | — | US | disclosed |
| US-3953461-A | CNS DEPRESSANTS, ANTIINFLAMMATORY AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1976-04-27 | — | — | US | disclosed |