Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 3/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.33 |
| ▸ | P4HB | P07237 | 1/20 | 0.33 |
| ▸ | MPL | P40238 | 2/20 | 0.33 |
| ▸ | GPR3 | P46089 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4716235 | 1.00 | KDM4E (0.40) | KDM4EAPPENPP2FDPSKIF11 | |
| SCHEMBL4716233 | 1.00 | KDM4E (0.40) | KDM4EAPPENPP2FDPSKIF11 | |
| SCHEMBL9005576 | 0.81 | NPFFR2 (0.47) | KDM4EAPPENPP2FDPSCTSS | |
| SCHEMBL9005571 | 0.81 | NPFFR2 (0.47) | KDM4EAPPENPP2FDPSCTSS | |
| SCHEMBL10331382 | 0.80 | NFE2L2 (0.52) | KDM4EENPP2FDPSNFE2L2P4HB | |
| SCHEMBL15282103 | 0.80 | NFE2L2 (0.52) | KDM4EENPP2FDPSNFE2L2P4HB | |
| SCHEMBL2089750 | 0.77 | APP (0.42) | APPKIF11ARNFE2L2MPL | |
| SCHEMBL29110062 | 0.77 | APP (0.42) | KDM4EAPPKIF11ARNFE2L2 | |
| SCHEMBL2089748 | 0.77 | APP (0.42) | APPKIF11ARNFE2L2MPL | |
| SCHEMBL29110066 | 0.77 | APP (0.42) | KDM4EAPPKIF11ARNFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1337517-B1 | PYRIMIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 2008-11-26 | — | — | EP | disclosed |