Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21784357 | 0.87 | PKM (0.54) | POLBHTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL350140 | 0.81 | PKM (0.61) | POLBHTTKDM4ENPC1RAB9A | |
| SCHEMBL7854448 | 0.81 | POLB (0.92) | POLBNPC1RAB9ACHRM1PDE10A | |
| SCHEMBL7006523 | 0.81 | POLB (1.00) | POLBNPC1RAB9ACHRM1PDE10A | |
| SCHEMBL1884521 | 0.80 | POLB (0.72) | POLBHTTKDM4ENPC1RAB9A | |
| SCHEMBL10045228 | 0.80 | POLB (0.62) | POLBHTTKDM4ELMNANPC1 | |
| SCHEMBL833457 | 0.80 | POLB (0.66) | POLBHTTKDM4ENPC1RAB9A | |
| SCHEMBL4716247 | 0.79 | POLB (0.66) | POLBHTTKDM4ELMNANPC1 | |
| SCHEMBL4714908 | 0.79 | BCHE (0.67) | LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4718043 | 0.79 | CYP2C9 (0.45) | POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216230-B1 | FUSED CYCLOHEPTANE AND FUSED AZACYCLOHEPTANE COMPOUNDS AND THEIR USE AS INTEGRIN RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2008-04-23 | — | — | EP | disclosed |