Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4717030 | 0.89 | MEN1 (0.43) | MEN1KMT2ALMNASMN1; SMN2HTT | |
| SCHEMBL1548782 | 0.89 | MEN1 (0.54) | MEN1KMT2ALMNASMN1; SMN2HTT | |
| SCHEMBL4716854 | 0.83 | MEN1 (0.53) | MEN1KMT2ALMNASMN1; SMN2HTT | |
| SCHEMBL1548742 | 0.76 | MEN1 (0.55) | MEN1KMT2ALMNASMN1; SMN2HTT | |
| SCHEMBL4716001 | 0.76 | LMNA (0.52) | MEN1KMT2ALMNASMN1; SMN2HTT | |
| SCHEMBL4715446 | 0.75 | HTT (0.41) | MEN1KMT2AHTTMITF | |
| SCHEMBL1548106 | 0.75 | MEN1 (0.42) | MEN1KMT2ALMNASMN1; SMN2HTT | |
| SCHEMBL1548632 | 0.74 | SPHK2 (0.53) | MEN1KMT2ALMNASMN1; SMN2SPHK2 | |
| SCHEMBL4715435 | 0.74 | LMNA (0.57) | MEN1KMT2ALMNASMN1; SMN2HTT | |
| SCHEMBL4718085 | 0.73 | MEN1 (0.76) | MEN1KMT2ALMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3952850-A1 | USE OF SK2 INHIBITORS IN COMBINATION WITH IMMUNE CHECKPOINT BLOCKADE THERAPY FOR THE TREATMENT OF CANCER | Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) | 2022-02-16 | — | — | EP | disclosed |
| WO-2020208060-A1 | USE OF SK2 INHIBITORS IN COMBINATION WITH IMMUNE CHECKPOINT BLOCKADE THERAPY FOR THE TREATMENT OF CANCER | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2020-10-15 | — | — | WO | disclosed |
| EP-1904439-A2 | SPHINGOSINE KINASE INHIBITORS | Apogee Biothechnology Corporation (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006138660-A2 | SPHINGOSINE KINASE INHIBITORS | APOGEE BIOTECHNOLOGY CORPORATION (US) | 2006-12-28 | — | — | WO | disclosed |