Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4716280 | 0.89 | MEN1 (0.52) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL1548782 | 0.78 | MEN1 (0.54) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4715446 | 0.75 | HTT (0.41) | MEN1KMT2AHTTEPHX2 | |
| SCHEMBL1548773 | 0.75 | MEN1 (0.41) | MEN1KMT2AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL22530506 | 0.75 | LMNA (0.44) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4716854 | 0.72 | MEN1 (0.53) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4717867 | 0.72 | OPRM1 (0.47) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL29387029 | 0.71 | HSD11B1 (0.39) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4717042 | 0.67 | LMNA (0.49) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4719213 | 0.66 | GRIN2D (0.50) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904439-A2 | SPHINGOSINE KINASE INHIBITORS | Apogee Biothechnology Corporation (US) | 2008-04-02 | — | — | EP | claimed |
| WO-2006138660-A2 | SPHINGOSINE KINASE INHIBITORS | APOGEE BIOTECHNOLOGY CORPORATION (US) | 2006-12-28 | — | — | WO | claimed |
| EP-3407912-B1 | METHODS FOR ENHANCING THE POTENCY OF THE IMMUNE CHECKPOINT INHIBITORS | INST NAT SANTE RECH MED (FR) | 2022-05-18 | — | — | EP | disclosed |
| EP-1904439-A2 | SPHINGOSINE KINASE INHIBITORS | Apogee Biothechnology Corporation (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006138660-A2 | SPHINGOSINE KINASE INHIBITORS | APOGEE BIOTECHNOLOGY CORPORATION (US) | 2006-12-28 | — | — | WO | disclosed |