Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | RAD52 | P43351 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | SPHK2 | Q9NRA0 | 4/20 | 0.46 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4717023 | 0.80 | EPHX2 (0.50) | MEN1KMT2ARAD52ALDH1A1EPHX2 | |
| SCHEMBL1548369 | 0.77 | SPHK2 (0.74) | MEN1KMT2ALMNARAD52HTT | |
| SCHEMBL4718400 | 0.77 | MEN1 (0.51) | MEN1KMT2ALMNARAD52HTT | |
| SCHEMBL4717890 | 0.77 | MEN1 (0.50) | MEN1KMT2ALMNARAD52HTT | |
| SCHEMBL1548625 | 0.77 | SPHK2 (0.45) | MEN1KMT2ALMNARAD52HTT | |
| SCHEMBL2734558 | 0.75 | LMNA (0.48) | MEN1KMT2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL4715435 | 0.74 | LMNA (0.57) | MEN1KMT2ALMNARAD52HTT | |
| SCHEMBL4718085 | 0.73 | MEN1 (0.76) | MEN1KMT2ALMNARAD52HTT | |
| SCHEMBL4716854 | 0.70 | MEN1 (0.53) | MEN1KMT2ALMNARAD52HTT | |
| SCHEMBL4718166 | 0.70 | LMNA (0.66) | MEN1KMT2ALMNARAD52HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904439-A2 | SPHINGOSINE KINASE INHIBITORS | Apogee Biothechnology Corporation (US) | 2008-04-02 | — | — | EP | claimed |
| WO-2006138660-A2 | SPHINGOSINE KINASE INHIBITORS | APOGEE BIOTECHNOLOGY CORPORATION (US) | 2006-12-28 | — | — | WO | claimed |
| EP-3407912-B1 | METHODS FOR ENHANCING THE POTENCY OF THE IMMUNE CHECKPOINT INHIBITORS | INST NAT SANTE RECH MED (FR) | 2022-05-18 | — | — | EP | disclosed |