Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 7/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4716332 | 0.80 | MEN1 (0.52) | EPHX2ALDH1A1MEN1RAD52KMT2A | |
| Hydrochloric Acid SCHEMBL1677979 | 0.74 | GRIN2D (0.52) | EPHX2P2RX7CHRM2CHRM1CHRM3 | |
| SCHEMBL1677866 | 0.74 | P2RX7 (0.47) | EPHX2P2RX7CHRM2CHRM1CHRM3 | |
| SCHEMBL1678084 | 0.72 | P2RX7 (0.46) | EPHX2P2RX7CHRM2CHRM1CHRM3 | |
| SCHEMBL1548570 | 0.71 | HDAC6 (0.51) | EPHX2TAAR1P2RX7HDAC6ALDH1A1 | |
| SCHEMBL4715282 | 0.70 | EPHX2 (0.64) | EPHX2P2RX7CHRM2CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL1677932 | 0.69 | EPHX2 (0.62) | EPHX2P2RX7CHRM2CHRM1CHRM3 | |
| SCHEMBL6793360 | 0.68 | TAAR1 (0.52) | TAAR1CHRM1CA12CA1CA2 | |
| SCHEMBL19173632 | 0.68 | CHRM2 (0.53) | EPHX2P2RX7CHRM2CHRM1CHRM3 | |
| SCHEMBL1677910 | 0.68 | MEN1 (0.61) | EPHX2CHRM2CHRM1CHRM3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904439-A2 | SPHINGOSINE KINASE INHIBITORS | Apogee Biothechnology Corporation (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006138660-A2 | SPHINGOSINE KINASE INHIBITORS | APOGEE BIOTECHNOLOGY CORPORATION (US) | 2006-12-28 | — | — | WO | disclosed |