Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.55 |
| ▸ | INSR | P06213 | 1/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | APAF1 | O14727 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5309365 | 0.85 | HIF1A (0.63) | HIF1AHDAC1HDAC2POLBKMT2A | |
| SCHEMBL6154003 | 0.80 | HIF1A (0.64) | HIF1AHDAC1HDAC2CA1CA2 | |
| SCHEMBL31527666 | 0.79 | TUBB4A (0.69) | HIF1AHDAC1HDAC2CA1CA2 | |
| SCHEMBL28532163 | 0.79 | PTPN7 (0.58) | HIF1AHDAC1HDAC2CA1CA2 | |
| SCHEMBL27182960 | 0.79 | TUBB4A (0.69) | HIF1AHDAC1HDAC2CA1CA2 | |
| SCHEMBL6140542 | 0.78 | HIF1A (0.66) | HIF1AHDAC1HDAC2CA1CA2 | |
| SCHEMBL11825145 | 0.78 | PDGFRB (0.50) | HIF1AHDAC1HDAC2CA1CA2 | |
| SCHEMBL1064897 | 0.78 | NR1H4 (0.67) | HIF1AHDAC1HDAC2CA1CA2 | |
| SCHEMBL30679030 | 0.77 | MAPT (0.57) | HIF1ACA1CA2TSHRPOLB | |
| SCHEMBL11835271 | 0.77 | MAPT (0.57) | HIF1ACA1CA2TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957073-A2 | MEDICINAL DRUG | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007066784-A2 | DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-06-14 | — | — | WO | disclosed |