Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4E | P06730 | 1/20 | 0.37 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 12/20 | 0.36 |
| ▸ | CNR2 | P34972 | 12/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1339161 | 0.90 | EIF4E (0.39) | EIF4EHPSECNR1CNR2KDM4E | |
| SCHEMBL1339436 | 0.89 | EIF4E (0.38) | EIF4EHPSECNR1CNR2KDM4E | |
| SCHEMBL1339047 | 0.88 | EIF4E (0.37) | EIF4EHPSECNR1CNR2KDM4E | |
| SCHEMBL1338822 | 0.88 | PARP1 (0.37) | EIF4EHPSECNR1CNR2KDM4E | |
| SCHEMBL1337068 | 0.87 | IDH1 (0.39) | EIF4ECNR1CNR2KDM4ENPC1 | |
| SCHEMBL1338539 | 0.86 | L3MBTL1 (0.37) | EIF4EHPSECNR1CNR2KDM4E | |
| SCHEMBL1337288 | 0.86 | GABRA1 (0.41) | EIF4EHPSECNR1CNR2KDM4E | |
| SCHEMBL1337140 | 0.84 | CNR1 (0.36) | EIF4EHPSECNR1CNR2KDM4E | |
| SCHEMBL1336976 | 0.84 | TRIM24 (0.41) | EIF4ECNR1CNR2KDM4ENPC1 | |
| SCHEMBL1339432 | 0.84 | CNR1 (0.40) | EIF4ECNR1CNR2KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940840-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007045758-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2007-04-26 | — | — | WO | disclosed |