Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 2/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MYC | P01106 | 2/20 | 0.43 |
| ▸ | MAX | P61244 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | PELP1 | Q8IZL8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718482 | 0.81 | GAA (0.58) | NPC1RAB9ASMN1; SMN2MYCMAX | |
| SCHEMBL27613394 | 0.78 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2CRHBPCRHR2 | |
| SCHEMBL2668279 | 0.72 | MEN1 (0.46) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL20672346 | 0.69 | TSHR (0.51) | NPC1RAB9ASMN1; SMN2CYP2C19KMT2A | |
| SCHEMBL15689544 | 0.68 | CTSD (0.65) | SMN1; SMN2CRHBPCRHR2KMT2AMEN1 | |
| SCHEMBL5797530 | 0.68 | ALDH1A1 (0.59) | NPC1RAB9ASMN1; SMN2MYCMAX | |
| SCHEMBL11995707 | 0.67 | MAPT (0.67) | RAB9ASMN1; SMN2CYP2C19KMT2AMEN1 | |
| SCHEMBL30733199 | 0.67 | MAPT (0.67) | RAB9ASMN1; SMN2CYP2C19KMT2AMEN1 | |
| SCHEMBL986256 | 0.67 | HTT (0.65) | NPC1RAB9ASMN1; SMN2CYP2C19KMT2A | |
| SCHEMBL19929388 | 0.67 | SMN1; SMN2 (0.44) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1452528-B1 | XANTHINE OXIDASE INHIBITORS | NIPPON CHEMIPHAR CO (JP) | 2008-08-13 | — | — | EP | disclosed |
| US-7253154-B2 | Substituted thiazolopyrimidines as xanthine oxidase inhibitors | NIPPON CHEMIPHAR CO., LTD. (JP) | 2007-08-07 | — | — | US | disclosed |
| EP-1452528-A1 | XANTHINE OXIDASE INHIBITORS | NIPPON CHEMIPHAR CO., LTD. (JP) | 2004-09-01 | — | — | EP | disclosed |