Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 3/20 | 0.46 |
| ▸ | CDK4 | P11802 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | CCND1 | P24385 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.44 |
| ▸ | RORB | Q92753 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30518910 | 0.85 | ALDH1A1 (0.58) | HSD17B10MCHR1KMT2ACDK5CDK5R1 | |
| SCHEMBL26051124 | 0.85 | ALDH1A1 (0.58) | HSD17B10MCHR1KMT2ACDK5CDK5R1 | |
| SCHEMBL4714235 | 0.84 | CNR2 (0.49) | CNR2LMNAALOX15HSD17B10MEN1 | |
| SCHEMBL22902557 | 0.79 | MEN1 (0.47) | LMNAALOX15HSD17B10MCHR1MEN1 | |
| SCHEMBL3219464 | 0.78 | KDM4E (0.52) | CNR2LMNAALOX15HSD17B10CDK1 | |
| SCHEMBL3222683 | 0.76 | TLR8 (0.57) | CNR2LMNAALOX15HSD17B10MEN1 | |
| SCHEMBL29658169 | 0.75 | CTSD (0.62) | CNR2LMNAALOX15HSD17B10HTT | |
| SCHEMBL322168 | 0.75 | CTSD (0.62) | CNR2LMNAALOX15HSD17B10HTT | |
| SCHEMBL1655885 | 0.75 | MCHR1 (0.56) | LMNAALOX15HSD17B10MCHR1MEN1 | |
| SCHEMBL3835745 | 0.75 | MAPK14 (0.50) | CNR2LMNAALOX15HSD17B10CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917245-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | Abbott GmbH & Co. KG (DE) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007022946-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBOTT GMBH & CO. KG (DE) | 2007-03-01 | — | — | WO | disclosed |