Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 13/20 | 0.47 |
| ▸ | CCR3 | P51677 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4717310 | 0.87 | KEAP1 (0.50) | NAMPTNPSR1 | |
| SCHEMBL4789267 | 0.86 | NAMPT (0.46) | NAMPT | |
| SCHEMBL14221973 | 0.83 | NAMPT (0.46) | NAMPT | |
| SCHEMBL14222058 | 0.83 | NAMPT (0.46) | NAMPT | |
| SCHEMBL4760969 | 0.82 | NAMPT (0.48) | NAMPT | |
| SCHEMBL4760017 | 0.81 | ITGB3 (0.54) | NAMPT | |
| SCHEMBL4762284 | 0.80 | ITGB3 (0.53) | NAMPT | |
| SCHEMBL4714544 | 0.79 | NAMPT (0.47) | NAMPT | |
| SCHEMBL4761797 | 0.79 | ITGB3 (0.53) | NAMPT | |
| SCHEMBL14222062 | 0.79 | NAMPT (0.48) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216230-B1 | FUSED CYCLOHEPTANE AND FUSED AZACYCLOHEPTANE COMPOUNDS AND THEIR USE AS INTEGRIN RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2008-04-23 | — | — | EP | disclosed |