Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A2 | P31639 | 15/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | LGALS1 | P09382 | 2/20 | 0.33 |
| ▸ | LGALS3 | P17931 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.32 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4081713 | 1.00 | SLC5A2 (0.36) | SLC5A2ABCB11ADORA3SLC5A1SLC6A4 | |
| SCHEMBL4718546 | 0.87 | TRPM5 (0.41) | SLC5A2SLC5A1SLC6A3LGALS3TRPM4 | |
| SCHEMBL4986893 | 0.82 | SLC5A2 (0.50) | SLC5A2 | |
| SCHEMBL4087278 | 0.82 | SLC5A2 (0.50) | SLC5A2 | |
| SCHEMBL4987870 | 0.82 | SLC5A2 (0.50) | SLC5A2 | |
| SCHEMBL4717027 | 0.82 | SLC5A2 (0.50) | SLC5A2 | |
| SCHEMBL19329994 | 0.79 | EPHX1 (0.43) | SLC5A2ABCB11ADORA3SLC5A1SLC6A4 | |
| SCHEMBL4077235 | 0.79 | EPHX1 (0.43) | SLC5A2ABCB11ADORA3SLC5A1SLC6A4 | |
| SCHEMBL4086552 | 0.79 | EPHX1 (0.43) | SLC5A2ABCB11ADORA3SLC5A1SLC6A4 | |
| SCHEMBL4078798 | 0.75 | SLC5A2 (0.46) | SLC5A2SLC5A1SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931631-A1 | 1- (1H- INDOL- 1-YL) -3- (METHYLAMINO) -1- PHENYLPROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) | Wyeth a Corporation of the State of Delaware (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007041023-A1 | 1- (1H- INDOL- 1-YL) -3- (METHYLAMINO) -1- PHENYLPROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) | WYETH (US) | 2007-04-12 | — | — | WO | disclosed |