Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM5 | Q9NZQ8 | 9/20 | 0.41 |
| ▸ | TRPM4 | Q8TD43 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SLC5A2 | P31639 | 6/20 | 0.34 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718151 | 0.87 | SLC5A2 (0.36) | TRPM5TRPM4SLC5A2SLC5A1SLC6A3 | |
| SCHEMBL4081713 | 0.87 | SLC5A2 (0.36) | TRPM5TRPM4SLC5A2SLC5A1SLC6A3 | |
| SCHEMBL4987870 | 0.75 | SLC5A2 (0.50) | SLC5A2 | |
| SCHEMBL4717027 | 0.75 | SLC5A2 (0.50) | SLC5A2 | |
| SCHEMBL4986893 | 0.75 | SLC5A2 (0.50) | SLC5A2 | |
| SCHEMBL4083576 | 0.75 | SLC5A2 (0.46) | TRPM5TRPM4CYP2C19SLC5A2 | |
| SCHEMBL4087278 | 0.75 | SLC5A2 (0.50) | SLC5A2 | |
| SCHEMBL4086552 | 0.72 | EPHX1 (0.43) | SLC5A2SLC5A1SLC6A3 | |
| SCHEMBL4077235 | 0.72 | EPHX1 (0.43) | SLC5A2SLC5A1SLC6A3 | |
| SCHEMBL4079821 | 0.72 | PTGS2 (0.41) | CYP2C19SLC5A2SLC5A1SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931631-A1 | 1- (1H- INDOL- 1-YL) -3- (METHYLAMINO) -1- PHENYLPROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) | Wyeth a Corporation of the State of Delaware (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007041023-A1 | 1- (1H- INDOL- 1-YL) -3- (METHYLAMINO) -1- PHENYLPROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) | WYETH (US) | 2007-04-12 | — | — | WO | disclosed |
| US-20070072897-A1 | Phenylaminopropanol derivatives and methods of their use | WYETH (US) | 2007-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072897-A1 | Phenylaminopropanol derivatives and methods of their use | COMT, PNMT, GLS | TRPM5 1575/4885TRPM4 1299/4885CYP2C19 359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.