Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.78 |
| ▸ | APP | P05067 | 1/20 | 0.78 |
| ▸ | GAA | P10253 | 1/20 | 0.78 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.78 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.78 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.58 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.58 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.58 |
| ▸ | F7 | P08709 | 1/20 | 0.53 |
| ▸ | F3 | P13726 | 1/20 | 0.53 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.53 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.53 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.53 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.53 |
| ▸ | KMO | O15229 | 1/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Niacin SCHEMBL28362910 | 0.89 | ALDH1A1 (0.72) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL29021368 | 0.89 | ALDH1A1 (0.78) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL28292236 | 0.88 | ALDH1A1 (1.00) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL29396199 | 0.88 | ALDH1A1 (1.00) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL150011 | 0.88 | ALDH1A1 (1.00) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL29349574 | 0.88 | — | — | |
| Niacin SCHEMBL30844065 | 0.88 | — | — | |
| Niacin SCHEMBL1433 | 0.88 | — | — | |
| Niacin SCHEMBL3081560 | 0.88 | ALDH1A1 (1.00) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL27676637 | 0.86 | ALDH1A1 (0.88) | ALDH1A1APPGAAHCAR3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104039323-A | Antibacterial compounds and methods of use | PTC THERAPEUTICS INC | 2014-09-10 | — | — | CN | claimed |
| WO-2022121844-A1 | DIHYDROPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 上海维申医药有限公司 | 2022-06-16 | — | — | WO | disclosed |
| CN-114014844-A | Aminopyridine derivatives and their use as selective ALK-2 inhibitors | 诺华股份有限公司 | 2022-02-08 | — | — | CN | disclosed |
| US-20200384188-A1 | SYSTEMS, DEVICES, FORMULATIONS AND METHODS FOR CONTROLLED DRUG DELIVERY | BEXSON BIOMEDICAL, INC. | 2020-12-10 | — | — | US | disclosed |
| EP-3710079-A1 | SYSTEMS, DEVICES, FORMULATIONS AND METHODS FOR CONTROLLED DRUG DELIVERY | Bexson Biomedical, Inc. (US) | 2020-09-23 | — | — | EP | disclosed |
| CN-105985320-B | Benzyl phthalazine compound and its preparation method and application | 复旦大学 | 2018-10-26 | — | — | CN | disclosed |
| CN-104039323-A | Antibacterial compounds and methods of use | PTC THERAPEUTICS INC | 2014-09-10 | — | — | CN | disclosed |
| CN-101910168-B | Tropane compounds | EXELIXIS INC | 2014-07-30 | — | — | CN | disclosed |
| CN-101448835-B | 6,7,8, 9-tetrahydro-5H-pyrimido [4,5-D ] azepin-4-yl ] -amine derivatives as TRPV1 modulators for the treatment of pain | JANSSEN PHARMACEUTICA NV | 2012-06-27 | — | — | CN | disclosed |
| CN-101910168-A | Tropane compounds | EXELIXIS INC | 2010-12-08 | — | — | CN | disclosed |
| CN-101448835-A | 6 as TRPV1 modulators for the treatment of pain | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-03 | — | — | CN | disclosed |
| CN-100469778-C | Novel fused imidazole derivatives | EISAI R&D MAN CO LTD (JP) | 2009-03-18 | — | — | CN | disclosed |
| EP-1940819-A1 | PHOSPHODIESTERASE 10 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2008-07-09 | — | — | EP | disclosed |
| CN-101098881-A | Macrolones - amino substituted quinolones | GLAXO GROUP LTD (GB) | 2008-01-02 | — | — | CN | disclosed |
| CN-100348599-C | Novel fused imidazole derivatives | EISAI CO LTD (JP) | 2007-11-14 | — | — | CN | disclosed |
| WO-2007022280-A1 | PHOSPHODIESTERASE 10 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |
| CN-1675208-A | Novel fused imidazole derivatives | EISAI CO LTD (JP) | 2005-09-28 | — | — | CN | disclosed |