Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 3/20 | 0.56 |
| ▸ | SLC17A5 | Q9NRA2 | 1/20 | 0.54 |
| ▸ | MDM4 | O15151 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | TNF | P01375 | 2/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8111105 | 0.96 | TLR2 (0.59) | TLR2SLC17A5MDM4TP53TNF | |
| SCHEMBL10073558 | 0.96 | TLR2 (0.59) | TLR2SLC17A5MDM4TP53TNF | |
| SCHEMBL7763897 | 0.92 | TLR2 (0.55) | TLR2SLC17A5MDM4TP53TNF | |
| SCHEMBL31461329 | 0.91 | TLR2 (0.57) | TLR2SLC17A5MDM4TP53TNF | |
| SCHEMBL16801838 | 0.90 | SLC17A5 (0.55) | TLR2SLC17A5MDM4TP53CASP3 | |
| SCHEMBL29456972 | 0.89 | SLC17A5 (0.51) | TLR2SLC17A5MDM4TP53TNF | |
| SCHEMBL29398108 | 0.89 | SLC17A5 (0.58) | TLR2SLC17A5MDM4TP53TNF | |
| SCHEMBL1486194 | 0.89 | SLC17A5 (0.58) | TLR2SLC17A5MDM4TP53TNF | |
| SCHEMBL6158264 | 0.88 | SLC17A5 (0.54) | TLR2SLC17A5MDM4TP53TNF | |
| SCHEMBL16801655 | 0.88 | SLC17A5 (0.54) | TLR2SLC17A5MDM4TP53CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101133060-B | Enzyme inhibitors | CHROMA THERAPEUTICS LTD | 2013-06-05 | — | — | CN | disclosed |
| CN-101133060-A | Enzyme inhibitors | CHROMA THERAPEUTICS LTD (GB) | 2008-02-27 | — | — | CN | disclosed |
| EP-1879895-A1 | ENZYME INHIBITORS | Chroma Therapeutics Limited (GB) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006117549-A1 | ENZYME INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2006-11-09 | — | — | WO | disclosed |