Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.52 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4717838 | 0.91 | SLC6A2 (0.66) | SLC6A2SLC6A4HRH3CARM1CYP2D6 | |
| SCHEMBL5475987 | 0.85 | SLC6A2 (0.50) | SLC6A2SLC6A4HRH3CARM1PRMT5 | |
| SCHEMBL4717610 | 0.83 | SLC6A2 (0.80) | SLC6A2SLC6A4HRH3CARM1 | |
| SCHEMBL4715306 | 0.79 | SLC6A2 (0.84) | SLC6A2SLC6A4HRH3CARM1 | |
| SCHEMBL4722396 | 0.79 | SLC6A2 (0.84) | SLC6A2SLC6A4HRH3CARM1 | |
| Hydrochloric Acid SCHEMBL27740771 | 0.79 | SLC6A2 (0.85) | SLC6A2SLC6A4HRH3CARM1 | |
| Hydrochloric Acid SCHEMBL5477784 | 0.79 | SLC6A2 (0.85) | SLC6A2SLC6A4HRH3CARM1 | |
| SCHEMBL4090139 | 0.78 | SLC6A2 (0.71) | SLC6A2SLC6A4 | |
| SCHEMBL4715366 | 0.78 | SLC6A2 (0.44) | SLC6A2SLC6A4HRH3CARM1PRMT5 | |
| SCHEMBL4718540 | 0.77 | ROCK1 (0.49) | SLC6A2SLC6A4CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931631-A1 | 1- (1H- INDOL- 1-YL) -3- (METHYLAMINO) -1- PHENYLPROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) | Wyeth a Corporation of the State of Delaware (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007041023-A1 | 1- (1H- INDOL- 1-YL) -3- (METHYLAMINO) -1- PHENYLPROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE MONOAMINE REUPTAKE FOR THE TREATMENT OF VASOMOTOR SYMPTOMS (VMS) | WYETH (US) | 2007-04-12 | — | — | WO | disclosed |
| US-20070072897-A1 | Phenylaminopropanol derivatives and methods of their use | WYETH (US) | 2007-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072897-A1 | Phenylaminopropanol derivatives and methods of their use | COMT, PNMT, GLS | SLC6A2 8/4885SLC6A4 16/4885HRH3 1760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.