Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | TEK | Q02763 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 6/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.42 |
| ▸ | LCK | P06239 | 5/20 | 0.42 |
| ▸ | BLK | P51451 | 5/20 | 0.42 |
| ▸ | SLK | Q9H2G2 | 5/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.42 |
| ▸ | MAP4K5 | Q9Y4K4 | 4/20 | 0.42 |
| ▸ | CSF1R | P07333 | 4/20 | 0.42 |
| ▸ | HIPK4 | Q8NE63 | 4/20 | 0.42 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.42 |
| ▸ | CLK2 | P49760 | 4/20 | 0.42 |
| ▸ | NEK2 | P51955 | 4/20 | 0.42 |
| ▸ | CSNK1G2 | P78368 | 4/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.42 |
| ▸ | FLT3 | P36888 | 4/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4720324 | 0.88 | TEK (0.51) | HTR2CTEKALDH1A1PKMKDR | |
| SCHEMBL4717817 | 0.78 | RAB9A (0.45) | TEKALDH1A1KDRMAP4K4LCK | |
| SCHEMBL4721836 | 0.78 | SMARCA2 (0.54) | HTR2CTEKPKMKDRMAP4K4 | |
| SCHEMBL4716748 | 0.76 | LCK (0.48) | HTR2CTEKALDH1A1PKMKDR | |
| SCHEMBL4718517 | 0.76 | ALDH1A1 (0.53) | TEKALDH1A1KDRMAP4K4LCK | |
| SCHEMBL13235026 | 0.74 | MAPK14 (0.69) | HTR2CALDH1A1NAMPTMAPK14SMN1; SMN2 | |
| SCHEMBL18236220 | 0.74 | HTR2C (0.60) | HTR2CALDH1A1PKMCLK4NAMPT | |
| SCHEMBL28415754 | 0.73 | HTR2C (0.60) | HTR2CALDH1A1PKMNAMPTMAPK14 | |
| SCHEMBL29946634 | 0.72 | HTR2C (0.55) | HTR2CALDH1A1PKMFLT3NAMPT | |
| SCHEMBL4719226 | 0.70 | KDR (0.58) | TEKALDH1A1KDRMAP4K4LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737462-B1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2008-07-30 | — | — | EP | claimed |
| EP-1737462-B1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2008-07-30 | — | — | EP | disclosed |
| US-20080027076-A1 | Pyrimidines With Tie2 (Tek) Activity | ASTRAZENECA AB (SE) | 2008-01-31 | — | — | US | disclosed |
| EP-1737462-A1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | AstraZeneca AB (SE) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005060969-A1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027076-A1 | Pyrimidines With Tie2 (Tek) Activity | TIE1, TEK, TEKT1 | HTR2C 3015/4885TEK 2/4885ALDH1A1 1331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.