Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16653268 | 0.81 | HDAC3 (0.46) | SIRT2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL16653270 | 0.81 | HDAC3 (0.46) | SIRT2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2458394 | 0.78 | SIRT2 (0.58) | SIRT2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL23920659 | 0.78 | SIRT2 (0.51) | SIRT2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL21356606 | 0.78 | DGAT1 (0.51) | SIRT2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL26551524 | 0.74 | SIRT2 (0.58) | SIRT2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL39113 | 0.74 | SIRT2 (0.61) | SIRT2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL29773981 | 0.74 | SIRT2 (0.61) | SIRT2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1562975 | 0.74 | SIRT2 (0.61) | SIRT2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL16765694 | 0.73 | SIRT2 (0.45) | SIRT2HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907398-A1 | THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2008-04-09 | — | — | EP | disclosed |
| EP-1877379-A1 | HYDROXYBENZAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF HSP90 | Astex Therapeutics Limited (GB) | 2008-01-16 | — | — | EP | disclosed |
| WO-2007011284-A1 | THERAPEUTIC AGENTS | ASTRAZENECA AB (SE) | 2007-01-25 | — | — | WO | disclosed |
| WO-2006109085-A1 | HYDROXYBENZAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF HSP90 | ASTEX THERAPEUTICS LIMITED (GB) | 2006-10-19 | — | — | WO | disclosed |