Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.97 |
| ▸ | CNR2 | P34972 | 4/20 | 0.75 |
| ▸ | POLB | P06746 | 1/20 | 0.75 |
| ▸ | ATM | Q13315 | 1/20 | 0.75 |
| ▸ | TP53 | P04637 | 5/20 | 0.72 |
| ▸ | NPC1 | O15118 | 1/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.72 |
| ▸ | RAB9A | P51151 | 1/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | CNR1 | P21554 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4743079 | 0.98 | SMN1; SMN2 (1.00) | SMN1; SMN2CNR2POLBATMTP53 | |
| SCHEMBL14100404 | 0.87 | SMN1; SMN2 (0.74) | SMN1; SMN2CNR2POLBATMTP53 | |
| SCHEMBL13532206 | 0.86 | TP53 (0.85) | SMN1; SMN2CNR2TP53NPC1HTT | |
| SCHEMBL4252422 | 0.86 | SMN1; SMN2 (0.77) | SMN1; SMN2CNR2TP53NPC1RAB9A | |
| SCHEMBL11176751 | 0.85 | SMN1; SMN2 (0.75) | SMN1; SMN2CNR2POLBATMTP53 | |
| SCHEMBL4717650 | 0.84 | TDP1 (0.97) | SMN1; SMN2CNR2POLBTP53NPC1 | |
| SCHEMBL4715327 | 0.84 | TDP1 (0.97) | SMN1; SMN2CNR2POLBTP53NPC1 | |
| SCHEMBL11818635 | 0.84 | TDP1 (0.71) | SMN1; SMN2CNR2POLBATMTP53 | |
| SCHEMBL11185044 | 0.82 | MAPK1 (0.77) | SMN1; SMN2CNR2TP53RAB9ATDP1 | |
| SCHEMBL4251116 | 0.82 | TDP1 (0.69) | SMN1; SMN2POLBTP53NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615904-B1 | SUBSTITUTED BENZOSULPHONAMIDES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ASTRAZENECA AB (SE) | 2008-02-27 | — | — | EP | claimed |
| WO-2008098025-A1 | ARYLSULFONAMIDE COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-14 | — | — | WO | disclosed |
| WO-2008098025-A1 | ARYLSULFONAMIDE COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-08-14 | — | — | WO | disclosed |
| EP-1615904-B1 | SUBSTITUTED BENZOSULPHONAMIDES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ASTRAZENECA AB (SE) | 2008-02-27 | — | — | EP | disclosed |