Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 8/20 | 0.48 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SCD | O00767 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5139452 | 0.82 | ELANE (0.64) | ELANENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL4720030 | 0.81 | ELANE (0.47) | ELANENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL30583373 | 0.80 | POLB (0.51) | ELANENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL18013093 | 0.80 | ELANE (0.65) | ELANENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL5834702 | 0.80 | NPC1 (0.50) | ELANENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL4720023 | 0.79 | RAB9A (0.60) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL4714502 | 0.79 | FAAH (0.40) | NPC1RAB9A | |
| SCHEMBL5835497 | 0.77 | NPC1 (0.45) | ELANENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL1990188 | 0.76 | KDM4E (0.53) | ELANENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL4686908 | 0.76 | NPC1 (0.55) | ELANENPC1RAB9ASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216230-B1 | FUSED CYCLOHEPTANE AND FUSED AZACYCLOHEPTANE COMPOUNDS AND THEIR USE AS INTEGRIN RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2008-04-23 | — | — | EP | disclosed |