Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 9/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4722951 | 0.93 | KMT2A (0.41) | SMN1; SMN2LMNAMEN1KMT2AMAPT | |
| SCHEMBL4724974 | 0.92 | NPC1 (0.40) | SMN1; SMN2LMNAMEN1KMT2AMAPT | |
| SCHEMBL4724043 | 0.91 | F10 (0.42) | SMN1; SMN2LMNAMEN1KMT2AMAPT | |
| SCHEMBL4722089 | 0.88 | PDE4A (0.36) | SMN1; SMN2LMNAMEN1KMT2AMAPT | |
| SCHEMBL4721953 | 0.87 | PDE4A (0.36) | SMN1; SMN2LMNAMEN1KMT2AMAPT | |
| SCHEMBL4720922 | 0.87 | F10 (0.39) | SMN1; SMN2LMNAMEN1KMT2AMAPT | |
| SCHEMBL4719833 | 0.87 | PDE4A (0.35) | SMN1; SMN2LMNAMEN1KMT2AMAPT | |
| SCHEMBL4723112 | 0.87 | PDE4A (0.39) | SMN1; SMN2LMNAMEN1KMT2AMAPT | |
| SCHEMBL4720454 | 0.86 | PDE4A (0.38) | SMN1; SMN2LMNAMEN1KMT2AMAPT | |
| SCHEMBL4719755 | 0.86 | MAPT (0.35) | SMN1; SMN2LMNAMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |