Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4722572 | 0.93 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4724138 | 0.93 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4720140 | 0.93 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4721953 | 0.92 | PDE4A (0.36) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4719449 | 0.91 | PDE4A (0.36) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4723364 | 0.90 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4720999 | 0.90 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4722089 | 0.90 | PDE4A (0.36) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4720454 | 0.90 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL4723445 | 0.89 | SMN1; SMN2 (0.35) | PDE4APDE4BPDE4CPDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |