Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 3/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 6/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 6/20 | 0.38 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4722632 | 0.92 | CENPE (0.42) | CENPETAS1R3TAS1R1KIFC1TOP2A | |
| SCHEMBL4717914 | 0.86 | CENPE (0.42) | CENPETAS1R3TAS1R1KIFC1TOP2A | |
| SCHEMBL3219681 | 0.80 | CENPE (0.51) | CENPETAS1R3TAS1R1KIFC1S1PR1 | |
| SCHEMBL4720739 | 0.80 | CENPE (0.45) | CENPETAS1R3TAS1R1KIFC1TOP2A | |
| SCHEMBL2617416 | 0.79 | CENPE (0.52) | CENPETAS1R3TAS1R1KIFC1S1PR1 | |
| SCHEMBL3462429 | 0.79 | CENPE (0.52) | CENPETAS1R3TAS1R1KIFC1S1PR1 | |
| SCHEMBL3228261 | 0.79 | CENPE (0.52) | CENPETAS1R3TAS1R1KIFC1S1PR1 | |
| SCHEMBL13644431 | 0.78 | CENPE (0.45) | CENPETAS1R3TAS1R1KIFC1S1PR1 | |
| SCHEMBL4718279 | 0.77 | CENPE (0.46) | CENPETAS1R3TAS1R1KIFC1TOP2A | |
| SCHEMBL3234403 | 0.76 | CENPE (0.51) | CENPETAS1R3TAS1R1KIFC1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | claimed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | claimed |