Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 3/20 | 0.45 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.34 |
| ▸ | F11 | P03951 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4717914 | 0.86 | CENPE (0.42) | CENPEKIFC1TOP2ATAS1R3TAS1R1 | |
| SCHEMBL3229213 | 0.81 | CENPE (0.51) | CENPEKIFC1TAS1R3TAS1R1S1PR1 | |
| SCHEMBL3461569 | 0.81 | CENPE (0.51) | CENPEKIFC1TAS1R3TAS1R1S1PR1 | |
| SCHEMBL13161447 | 0.81 | CENPE (0.51) | CENPEKIFC1TAS1R3TAS1R1S1PR1 | |
| SCHEMBL4722632 | 0.80 | CENPE (0.42) | CENPEKIFC1TOP2ATAS1R3TAS1R1 | |
| SCHEMBL4720522 | 0.80 | CENPE (0.43) | CENPEKIFC1TOP2ATAS1R3TAS1R1 | |
| SCHEMBL13644414 | 0.79 | CENPE (0.47) | CENPEKIFC1TOP2ATAS1R3TAS1R1 | |
| SCHEMBL4718875 | 0.78 | CENPE (0.45) | CENPEKIFC1TOP2ATAS1R3TAS1R1 | |
| SCHEMBL3219624 | 0.77 | CENPE (0.52) | CENPEKIFC1TAS1R3TAS1R1S1PR1 | |
| SCHEMBL2104729 | 0.77 | SIRT2 (0.46) | CENPEKIFC1TAS1R3TAS1R1PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951719-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056469-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |