SCHEMBL4720667

SCHEMBL4720667

O=Cc1ccc([N+]2([O-])CCCCC2)cc1

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.41
KDM4E B2RXH2 3/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
TRIM24 O15164 1/20 0.38
TRIM33 Q9UPN9 1/20 0.38
CYP2A6 P11509 4/20 0.37
HSD17B10 Q99714 1/20 0.37
ALDH5A1 P51649 1/20 0.37
ABAT P80404 1/20 0.37
TYR P14679 1/20 0.33
CYP2A13 Q16696 1/20 0.33
ALDH1A3 P47895 3/20 0.32
ALDH3A1 P30838 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4624512 0.76 CYP2A6 (0.41) ALDH1A1KDM4ESMN1; SMN2TRIM24TRIM33
SCHEMBL4626949 0.73 CYP2A6 (0.43) ALDH1A1KDM4ESMN1; SMN2TRIM24TRIM33
SCHEMBL7854918 0.73 HCAR2 (0.50) ALDH1A1KDM4ESMN1; SMN2HSD17B10TYR
SCHEMBL13719990 0.72
SCHEMBL76934 0.72 MEN1 (0.36) ALDH1A1KDM4EHSD17B10
SCHEMBL874303 0.72
SCHEMBL1946653 0.72 KMT2A (0.38) ALDH1A1SMN1; SMN2
SCHEMBL3984911 0.72 KMT2A (0.36) ALDH1A1KDM4EHSD17B10TYR
SCHEMBL6074470 0.72 PIM1 (0.55)
SCHEMBL6848401 0.72 ALDH1A1 (0.35) ALDH1A1KDM4ESMN1; SMN2TRIM24TRIM33

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1675847-A4 SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE ADOLOR CORP (US) 2008-08-20 EP disclosed
EP-1883451-A2 SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY Neuraxon Inc. (CA) 2008-02-06 EP disclosed
EP-1871761-A2 SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE Adolor Corporation (US) 2008-01-02 EP disclosed
WO-2007063418-A2 SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY NEURAXON, INC. (CA) 2007-06-07 WO disclosed
WO-2006105442-A2 SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE ADOLOR CORPORATION (US) 2006-10-05 WO disclosed
EP-1675847-A2 SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE Adolor Corporation (US) 2006-07-05 EP disclosed
EP-1501507-A4 TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO INC (US) 2006-05-17 EP disclosed
WO-2005033073-A2 SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE ADOLOR CORPORATION (US) 2005-04-14 WO disclosed
EP-1501507-A2 TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Merck & Co., Inc. (US) 2005-02-02 EP disclosed
EP-1414813-A1 1,2,4-TRIOXOLANE ANTIMALARIALS Medicines for Malaria Venture (CH) 2004-05-06 EP disclosed
EP-0858451-A1 PHARMACEUTICALLY ACTIVE QUINAZOLINE COMPOUNDS Astra Pharmaceuticals Limited (GB) 1998-08-19 EP disclosed
EP-0431943-B1 Spiro(pyran)piperidine derivatives MERCK & CO INC (US) 1998-07-15 EP disclosed
WO-1997040050-A1 THIENOPYRIDINE DERIVATIVES AND THEIR USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-10-30 WO disclosed
WO-1997014686-A1 PHARMACEUTICALLY ACTIVE QUINAZOLINE COMPOUNDS ASTRA PHARMACEUTICALS LIMITED (GB) 1997-04-24 WO disclosed
EP-0705258-A1 AZOLYL-CYCLIC AMINE DERIVATIVES WITH IMMUNOMODULATORY ACTIVITY Knoll AG (DE) 1996-04-10 EP disclosed
EP-0686085-A4 PROCESS OF MAKING MICROPOROUS PPS MEMBRANES DOW CHEMICAL CO (US) 1996-03-13 EP disclosed
EP-0686085-A1 PROCESS OF MAKING MICROPOROUS PPS MEMBRANES THE DOW CHEMICAL COMPANY (US) 1995-12-13 EP disclosed
EP-0682591-A1 PROCESS OF MAKING MICROPOROUS PPS MEMBRANES THE DOW CHEMICAL COMPANY (US) 1995-11-22 EP disclosed
WO-1994017985-A1 PROCESS OF MAKING MICROPOROUS PPS MEMBRANES THE DOW CHEMICAL COMPANY (US) 1994-08-18 WO disclosed
WO-1994017974-A1 PROCESS OF MAKING MICROPOROUS PPS MEMBRANES THE DOW CHEMICAL COMPANY (US) 1994-08-18 WO disclosed