Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.38 |
| ▸ | IDH1 | O75874 | 4/20 | 0.36 |
| ▸ | IDH2 | P48735 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8345900 | 0.80 | HDAC3 (0.42) | HDAC3NCOR1HDAC4HDAC1HDAC7 | |
| SCHEMBL12963514 | 0.78 | HDAC3 (0.40) | HDAC3NCOR1HDAC4HDAC1HDAC7 | |
| SCHEMBL12933370 | 0.78 | HDAC3 (0.40) | HDAC3NCOR1HDAC4HDAC1HDAC7 | |
| SCHEMBL27481252 | 0.75 | HDAC3 (0.44) | HDAC3NCOR1HDAC4HDAC1HDAC7 | |
| SCHEMBL29906009 | 0.74 | SYK (0.43) | HDAC3NCOR1HDAC4HDAC1HDAC7 | |
| SCHEMBL1184986 | 0.74 | SYK (0.43) | HDAC3NCOR1HDAC4HDAC1HDAC7 | |
| SCHEMBL15390391 | 0.74 | KMT2A (0.61) | HDAC3NCOR1HDAC4HDAC1HDAC7 | |
| SCHEMBL29712950 | 0.73 | ALDH1A1 (0.47) | HDAC3NCOR1HDAC4HDAC1HDAC7 | |
| SCHEMBL29390964 | 0.73 | HDAC3 (0.42) | HDAC3NCOR1HDAC4HDAC1HDAC7 | |
| SCHEMBL18227222 | 0.73 | HDAC3 (0.38) | HDAC3NCOR1HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893588-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | Boehringer Ingelheim International GmbH (DE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006135826-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-12-21 | — | — | WO | disclosed |