Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | HTR2B | P41595 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.33 |
| ▸ | UGCG | Q16739 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4720300 | 0.90 | SMPD3 (0.35) | PDE4APDE4BPDE4CPDE4DKCNK3 | |
| SCHEMBL4720304 | 0.90 | SMPD3 (0.35) | PDE4APDE4BPDE4CPDE4DKCNK3 | |
| SCHEMBL4722298 | 0.90 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DTGFBR1 | |
| SCHEMBL4720459 | 0.89 | F10 (0.40) | MAPTF2F10 | |
| SCHEMBL4724946 | 0.87 | TDP1 (0.39) | MAPTF2F10ALDH1A1HPGD | |
| SCHEMBL4724533 | 0.87 | SMPD3 (0.46) | — | |
| SCHEMBL4724531 | 0.87 | SMPD3 (0.46) | — | |
| SCHEMBL4724669 | 0.87 | MAPT (0.35) | MAPTF2F10MEN1ALDH1A1 | |
| SCHEMBL14101733 | 0.80 | F10 (0.38) | MAPTF2F10MEN1ALDH1A1 | |
| SCHEMBL4724420 | 0.79 | P2RX7 (0.35) | F2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |