Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4722191 | 1.00 | HSD11B1 (0.39) | HSD11B1PDE3BPDE3AP2RX7KDM4E | |
| SCHEMBL4723155 | 0.93 | PDE3B (0.39) | HSD11B1PDE3BPDE3AP2RX7KDM4E | |
| SCHEMBL4723162 | 0.93 | PDE3B (0.39) | HSD11B1PDE3BPDE3AP2RX7KDM4E | |
| SCHEMBL4721179 | 0.92 | P2RX7 (0.41) | HSD11B1PDE3BPDE3AP2RX7MAPT | |
| SCHEMBL4722700 | 0.92 | P2RX7 (0.41) | PDE3BPDE3AP2RX7KDM4ERORC | |
| SCHEMBL4724017 | 0.92 | PDE3B (0.38) | HSD11B1PDE3BPDE3AP2RX7RORC | |
| SCHEMBL4721174 | 0.92 | P2RX7 (0.41) | HSD11B1PDE3BPDE3AP2RX7MAPT | |
| SCHEMBL4724024 | 0.92 | PDE3B (0.38) | HSD11B1PDE3BPDE3AP2RX7RORC | |
| SCHEMBL4722703 | 0.92 | P2RX7 (0.41) | PDE3BPDE3AP2RX7KDM4ERORC | |
| SCHEMBL4721096 | 0.92 | P2RX7 (0.41) | HSD11B1PDE3BPDE3AP2RX7MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1953147-A1 | HETEROCYCLIC COMPOUND AND MEDICINAL APPLICATION THEREOF | Japan Tobacco, Inc. (JP) | 2008-08-06 | — | — | EP | disclosed |