Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | HTR1B | P28222 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 3/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4723715 | 0.92 | NPC1 (0.39) | ALOX15NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4724232 | 0.87 | MAPT (0.40) | ALOX15NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4723665 | 0.80 | NPC1 (0.43) | ALOX15NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4723327 | 0.79 | LTA4H (0.36) | RAB9ATDP1L3MBTL1 | |
| SCHEMBL4765802 | 0.72 | ALOX15 (0.37) | ALOX15NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4724870 | 0.68 | TLR8 (0.37) | ALOX15CNR2TDP1HTR1BGAA | |
| Decane SCHEMBL9931523 | 0.66 | CNR1 (0.51) | ALOX15NPC1MAPTRAB9ASMN1; SMN2 | |
| Tetradecane SCHEMBL9931525 | 0.66 | CNR1 (0.51) | ALOX15NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL28437262 | 0.66 | CNR2 (0.48) | NPC1RAB9ASMN1; SMN2CNR2TDP1 | |
| SCHEMBL25558632 | 0.66 | SMN1; SMN2 (0.35) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874780-A1 | 4-PIPERAZINYLTHIENO[2,3-D]PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | Pharmacia & Upjohn Company LLC (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006100591-A1 | 4-PIPERAZINNYLTHIENO [2,3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-09-28 | — | — | WO | disclosed |