Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.52 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.52 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.52 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CETP | P11597 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8806924 | 0.87 | CA12 (0.59) | LMNAKDM4EALOX12PDK1PDK2 | |
| SCHEMBL9872617 | 0.87 | KDM4E (0.56) | LMNAKDM4EALOX12PDK1PDK2 | |
| SCHEMBL1030263 | 0.82 | LMNA (0.74) | LMNAKDM4EALOX12PDK1PDK2 | |
| SCHEMBL11463578 | 0.82 | ALDH1A1 (0.48) | LMNAKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL4935684 | 0.81 | CA12 (0.50) | LMNAKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL11455556 | 0.81 | ALDH1A1 (0.47) | LMNAKDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL18021884 | 0.80 | LMNA (0.58) | LMNAKDM4EALOX12PDK1PDK2 | |
| SCHEMBL999403 | 0.79 | LMNA (0.55) | LMNAKDM4EALOX12PDK1PDK2 | |
| SCHEMBL7928023 | 0.79 | LMNA (0.57) | LMNAKDM4EALOX12PDK1PDK2 | |
| SCHEMBL10046356 | 0.79 | KDM4E (0.57) | LMNAKDM4EALOX12PDK1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940835-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007036733-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |